ProTAME is a novel inhibitor of APC/CFzr and APC/CCdc20 with anticancer activity. It acts as a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20). It arrests cells in metaphase without perturbing the spindle, but is dependent on the spindle assembly checkpoint (SAC). Combinations of proTAME with topoisomerase inhibitors, etoposide and doxorubicin, significantly increase cell death in Multiple Myeloma (MM) cell lines and primary cells, particularly if TOPIIα levels are first increased through pre-treatment with ProTAME.

纯度：≥98%

CAS：1362911-19-0