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proTAME
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
proTAME图片
CAS NO:1362911-19-0
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

ProTAME is a novel inhibitor of APC/CFzr and APC/CCdc20 with anticancer activity. It acts as a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20). It arrests cells in metaphase without perturbing the spindle, but is dependent on the spindle assembly checkpoint (SAC). Combinations of proTAME with topoisomerase inhibitors, etoposide and doxorubicin, significantly increase cell death in Multiple Myeloma (MM) cell lines and primary cells, particularly if TOPIIα levels are first increased through pre-treatment with ProTAME.

纯度:≥98%

CAS:1362911-19-0