| 规格: | 98% |
| 分子量: | 468.5 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
Background:
NUCC-390 is a chemokine (C-X-C motif) receptor 4 (CXCR4) agonist.1It induces calcium mobilization in C8161 melanoma cells expressing CXCR4 when used at a concentration of 10 µM, an effect that can be prevented by the CXCR4 antagonist AMD3100 . NUCC-390 (0.0625, 0.125, and 0.25 µM) increases axon length in cultured rat spinal cord motor neurons.2In vivo, NUCC-390 (26 mg/kg per day) restores gastrocnemius muscle compound muscle action potentials (CMAPs) in a mouse model of sciatic nerve crush injury. It also restores CMAPs in a mouse model of neuroparalysis induced by Papuan taipan (O. scutellatus) venom.3
1.Mishra, R.K., Shum, A.K., Platanias, L.C., et al.Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonistsSci. Rep.6:301551-9(2016) 2.Zanetti, G., Negro, S., Megighian, A., et al.A CXCR4 receptor agonist strongly stimulates axonal regeneration after damageAnn. Clin. Transl. Neurol.6(12)2395-2402(2019) 3.Stazi, M., D'Este, G., Mattarei, A., et al.An agonist of the CXCR4 receptor accelerates the recovery from the peripheral neuroparalysis induced by Taipan snake envenomationPLoS Negl. Trop. Dis.14(9)e0008547(2020)
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