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Spermidine-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Spermidine-d6图片
规格:98%
分子量:151.3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of spermidine
货号:ajcx25642
CAS:2514812-10-1
分子式:C7H13D6N3
分子量:151.3
溶解度:Water: 50 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Spermidine-d6is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine.1It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay.1It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan ofD. melanogaster, yeast, andC. elegans.2Spermidine (30 mM in the drinking water) reduces demyelination of the optic nerve and disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).3It reduces increases in blood pressure, left ventricular posterior wall thickness, and heart weight in salt-sensitive Dahl rats fed a high-salt diet, a model of hypertension-induced congestive heart failure.4Formulations containing spermidine have been used as dietary supplements.


1.Madeo, F., Eisenberg, T., Pietrocola, F., et al.Spermidine in health and diseaseScience359(6374)eaan2788(2018) 2.Eisenberg, T., Knauer, H., Schauer, A., et al.Induction of autophagy by spermidine promotes longevityNat. Cell Biol.11(11)1305-1314(2009) 3.Guo, X., Harada, C., Namekata, K., et al.Spermidine alleviates severity of murine experimental autoimmune encephalomyelitisInvest. Ophthalmol. Vis. Sci.52(5)2696-2703(2011) 4.Eisenberg, T., Abdellatif, M., Schroeder, S., et al.Cardioprotection and lifespan extension by the natural polyamine spermidineNat. Med.22(12)1428-1438(2016)