L-Serine-13C3 ((-)-Serine-13C3) 是 13C 标记的 L-丝氨酸。 L-丝氨酸（(-)-丝氨酸；(S)-丝氨酸），一种所谓的非必需氨基酸，在细胞增殖中起核心作用。
货号:ajcx25790
CAS:201595-68-8
分子式:[13C]3H7O3
分子量：108.1
溶解度:Water: slightly, sonicated
纯度：98%
存储：Store at -20°C
库存：现货

Background:

L-Serine-¹³C₃is intended for use as an internal standard for the quantification of L-serine by GC- or LC-MS. L-Serine is a non-essential amino acid.¹It is produced from 3-phosphoglycerate in a multistep biosynthesis catalyzed by phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP). L-Serine can also be derived from dietary sources, as well as protein and phospholipid turnover. Defective L-serine biosynthesis is associated with neural tube defects and deoxysphingolipid accumulation in patients with Neu-Laxova syndrome, a rare disease characterized by a mutation inPGDH.^1,2Dysregulation of L-serine phosphorylation is associated with disease progression in patients with neurodegenerative diseases, including Alzheimer’s disease and amyotrophic lateral sclerosis.

1.Holm, L.J., and Buschard, K.L-serine: A neglected amino acid with a potential therapeutic role in diabetesAPMIS127(10)655-659(2019) 2.Metcalf, J.S., Dunlop, R.A., Powell, J.T., et al.L-serine: A naturally-occurring amino acid with therapeutic potentialNeurotox. Res.33(1)213-221(2018)