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Hypoxanthine-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hypoxanthine-d4图片
规格:98%
分子量:140.1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
An internal standard for the quantification of hypoxanthine
货号:ajcx25908
CAS:2483831-32-7
分子式:C5D4N4O
分子量:140.1
溶解度:DMSO: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:


Hypoxanthine-d4is intended for use as an internal standard for the quantification of hypoxanthine by GC- or LC-MS. Hypoxanthine is an endogenous purine derivative and the major purine involved in the purine salvage pathway in the brain.1Intrastriatal administration of hypoxanthine (10 µM) increases mitochondrial complex II, also known as succinate dehydrogenase, activity and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rats. Hypoxanthine also induces hyperuricemia in mice.2Spinal fluid levels of hypoxanthine are increased in patients with Lesh-Nyhan syndrome, an inborn error of metabolism characterized by cognitive deficits, motor dysunction, self-mutilation, and hyperuricemia.


1.Biasibetti-Brendler, H., Schmitz, F., Pierozan, P., et al.Hypoxanthine induces neuroenergetic impairment and cell death in striatum of young adult Wistar ratsMol. Neurobiol.55(5)4098-4106(2018) 2.Yong, T., Zhang, M., Chen, D., et al.Actions of water extract from Cordyceps militaris in hyperuricemic mice induced by potassium oxonate combined with hypoxanthineJ. Ethnopharmacol.194403-411(2016)