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EM-12
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EM-12图片
规格:98%
分子量:244.2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A thalidomide derivative with teratogenic activity
货号:ajcx25992
CAS:26581-81-7
分子式:C13H12N2O3
分子量:244.2
溶解度:DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:


EM-12 is a derivative of thalidomide with teratogenic activity.1Intravenous administration of EM-12 (150 mg/kg) to pregnant females induces fetal resorption and skeletal malformation in surviving offspring in rats, rabbits, and rhesus monkeys. Dietary administration of EM-12 (12% w/w) enhances 1,2-dimethylhydrazine-induced colonic adenocarcinoma formation in rats.2


1.Schumacher, H.J., Terapane, J., Jordan, R.L., et al.The teratogenic activity of a thalidomide analogue, EM12 in rabbits, rats, and monkeysTeratology5(2)233-240(1972) 2.Gershbein, L.L.The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomasCancer Lett.60(2)129-133(1991)