RemdesivirO-desphosphateacetonideimpurity是Remdesivir的杂质。Remdesivir(GS-5734)是一种具有有效抗病毒活性的核苷类似物，有潜力用于2019-nCoV(COVID-19)研究。
货号:ajcx31396
CAS:1191237-80-5
分子式:C15H17N5O4
分子量：331.33
溶解度:DMSO: 100 mg/mL (301.81 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].

Remdesivir O-desphosphate acetonide impurity (analogue 21) is a 2′,3′-acetonide protected analogue of Remdesivir[1].

[1]. Dustin Siegel, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661. [2]. Manli Wang, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.