SJF620是一种PROTACBTK降解剂，DC50为7.9nM。SJF620含有Lenalidomide类似物，可募集CRBN。
货号:ajcx31476
CAS:2376187-16-3
分子式:C41H44N8O7
分子量：760.84
溶解度:DMSO: 100 mg/mL (131.43 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].

SJF620 is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA[1].

SJF620 has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1].

[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.