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(Rac)-Acolbifene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(Rac)-Acolbifene图片
规格:98%
分子量:457.56
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
(Rac)-Acolbifene(EM-343;(Rac)-EM-652)是EM652(estrogenreceptor拮抗剂)的外消旋形式,具有抗雌激素和雌激素活性。(Rac)-Acolbifene(EM-343;(Rac)-EM-652)含哌啶环,具有良好的药理作用,RBA=380。
货号:ajcx31870
CAS:151533-34-5
分子式:C29H31NO4
分子量:457.56
溶解度:DMSO: 100 mg/mL (218.55 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

(Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380[1].

(Rac)-Acolbifene (EM-343; (Rac)-EM-652) shows a inhibitory effect in T-47D cells with an IC50 value of 0.110 nM[1]. Cell Viability Assay[1] Cell Line: T-47D cells

(Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice)[1].

[1]. Gauthier S1,et al.Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution.J Enzyme Inhib Med Chem. 2005 Apr;20(2):165-77.