(E/Z)-IT-603是E-IT-603和Z-IT-603(IT-603)的混合物。IT-603是一种c-Rel抑制剂，其IC50值为3μM。IT-603具有抗癌活性。(E/Z)-IT-603有望作为调节剂调节移植物抗宿主病和恶性病中的T细胞反应。
货号:ajcx32016
CAS:292168-90-2
分子式:C11H9BrN2O3S
分子量：329.17
溶解度:DMSO: 125 mg/mL (379.74 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases[1].

[1]. Yusuke Shono, et al. A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity. Cancer Discov. 2014 May; 4(5): 578-591.