Manganese(salen) chloride (EUK-8)，一种超氧化物歧化酶和过氧化氢酶模拟物，是具有氧自由基清除性能的抗氧化剂。Manganese(salen) chloride 可减轻内毒素血症猪的急性肺损伤。
货号:ajcx32728
CAS:53177-12-1
分子式:C16H14ClMnN2O2
分子量：356.69
溶解度:DMSO : 8.33 mg/mL (23.35 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2].

Manganese(salen) chloride (25 µM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation[2].

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3].

参考文献:
[1]. Gonzalez PK, et, al. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J Pharmacol Exp Ther. 1995 Nov;275(2):798-806.
[2]. Bruce AJ, et, al. beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2312-6.
[3]. Empel VPM, et, al. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol. 2006 Aug 15;48(4):824-32.