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Lenalidomide-I
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lenalidomide-I图片
规格:98%
分子量:370.14
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
Lenalidomide-I 是一种用于 E3 泛素连接酶的 cereblon (CRBN) 配体 Lenalidomide 的类似物,用于 CRBN 蛋白的募集。Lenalidomide-I 可通过 linker 连接到蛋白质配体上形成 PROTAC,如 PROTAC BET 降解剂 QCA570 。
货号:ajcx33146
CAS:2207541-30-6
分子式:C13H11IN2O3
分子量:370.14
溶解度:DMSO : 25 mg/mL (67.54 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 [1].

Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

[1]. Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.