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(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH图片
规格:98%
分子量:754.98
包装与价格:
包装价格(元)
10mg电议
25mg电议

产品介绍
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) 是一种 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate) ,包含 VHL 配体。
货号:ajcx34212
CAS:2086301-47-3
分子式:C39H58N6O7S
分子量:754.98
溶解度:DMSO : 220 mg/mL (291.40 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[1]. Yimin Qian, et al. Compounds and methods for the targeted degradation of bromodomain-containing proteins. WO2017030814A1.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-991.