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CCF0058981
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CCF0058981图片
规格:98%
分子量:442.9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
CCF0058981 (CCF981) 是一种 3-氯苯基类似物,一种非共价SARS-CoV-2 3CLpro (SC2) 抑制剂,IC50 为 68 nM。CCF0058981 抑制SC1 (SARS-CoV-1 3CLpro),IC50 为 19 nM。CCF0058981 具有抗病毒功效,具有用于 COVID-19 研究的潜力。
货号:ajcx36348
CAS:N/A
分子式:C24H19ClN6O
分子量:442.9
溶解度:DMSO : 25 mg/mL (56.45 mM; ultrasonic and adjust pH to 2 with HCl)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CLpro (SC2) inhibitor with an IC50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CLpro) with an IC50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COVID-19 research[1].

CCF0058981 (CCF981) has cytopathic effect (CPE) inhibition (EC50=497 nM) and plaque reduction (EC50=558 nM) in vitro viral replication[1]. CCF0058981 has the 50% cytotoxic concentration (CC50) in the CPE antiviral assay of >50 μM[1]. CCF0058981 has a T1/2 of 21.1 min, a CLlnt of 141 mL/min•kg in Human liver microsomes[1].

[1]. Sang Hoon Han, et al. Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL pro). J Med Chem. 2021 Aug 4;acs.jmedchem.1c00598.