Suberosin 可从Plumbago zeylanica 分离得到，具有抗炎和抗血凝的活性。Suberosin 可通过调节NF-AT 和NF-κB，抑制PHA-诱导的 PBMC细胞增殖并捕获细胞周期G1过渡到 S期。
货号:ajcx15750
CAS:581-31-7
分子式:C15H16O3
分子量：244.29
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2].

[1]. Y-C Chen, et al. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-jB. British Journal of Pharmacology (2007) 150, 298-312. [2]. Golfakhrabadi F, et al. Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation of Ferulago carduchorum in rats. Pharm Biol. 2014 Oct;52(10):1335-40.