| 规格: | 98% |
| 分子量: | 153.1 |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
Background:
2-Fluoroadenine is a heterocyclic building block that has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activityin vitro.1It is also cytotoxic to CEM human leukemia cells with an IC50value of 0.15 µM.2
1.Llauger, L., He, H., Kim, J., et al.Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90J. Med. Chem.48(8)2892-2905(2005) 2.Parker, W.B., Allan, P.W., Shaddix, S.C., et al.Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cellsBiochem. Pharmacol.55(10)1673-1681(1998)
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