A neuropeptide with diverse biological activities
货号:ajcx22746
CAS:N/A
分子式:C21H15D5ClNO3
分子量：374.9
溶解度:DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 12.5 mg/ml,Ethanol: 3.3 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

JWH 203 N-pentanoic acid metabolite-d₅contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of JWH 203 N-pentanoic acid metabolite by GC-or LC-mass spectrometry. JWH 203 is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid (CB) agonist with K_ivalues of 8.0 and 7.0 nM at the central (CB₁) and peripheral (CB₂) receptors, respectively.¹Similar to the related 2'-methoxy compound JWH 250 , JWH 203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole CB compounds. Compared to JWH 250, JWH 203 displays slightly more potent binding affinities for the CB₁and CB₂CB receptors (JWH 250 K_is = 11 and 33 nM, respectively).¹JWH 203 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 203 that would be detectable both in serum and in urine. JWH 203 is a synthetic cannabinoid (CB) that displays high affinities for both the central CB₁receptor (K_i= 8.0 nM) and the peripheral CB₂receptor (K_i= 7.0 nM).¹. JWH 203 N-pentanoic acid metabolite is an expected metabolite of JWH 203, based on the metabolism of similar compounds.²The physiological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.

1.Huffman, J.W., Szklennik, P.V., Almond, A., et al.1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indolesBioorg. Med. Chem. Lett.15(18)4110-4113(2005) 2.Moran, C.L., Le, V.H., Chimalakonda, K.C., et al.Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urineAnal. Chem.83(11)4228-4236(2011)