An antagonist of muscle-type nAChRs
货号:ajcx23230
CAS:N/A
分子式:C35H60N2O4.2Br [XH2O]
分子量：732.7
溶解度:DMF: 5 mg/ml,DMSO: 5 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pancuronium is an aminosteroid antagonist of muscle-type nicotinic acetylcholine receptors (nAChRs) with an IC₅₀value of 14.8 nM using patch clamp electrophysiology in BOSC23 cells expressing mouse nAChRs.¹It acts as a non-depolarizing neuromuscular blocking agent.²Pancuronium enhances anesthesia induced by isoflurane , reducing immobilization with an ED₅₀value of 1.62 µg/kg.³

1.Liu, M., and Dilger, J.P.Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptorMol. Pharmacol.75(1)166-173(2009) 2.Buckett, W.R., Marjoribanks, C.E., Marwick, F.A., et al.The pharmacology of pancuronium bromide (Org.NA97), a new potent steroidal neuromuscular blocking agentBr. J. Pharmacol. Chemother.32(3)671-682(1968) 3.Miyazaki, Y., Sunaga, H., Hobo, S., et al.Pancuronium enhances isoflurane anesthesia in rats via inhibition of cerebral nicotinic acetylcholine receptorsJ. Anesth.30(4)671-676(2016)