A neuropeptide with diverse biological activities
货号:ajcx23432
CAS:N/A
分子式:C22H12D6N6.HCl
分子量：408.9
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Rilpivirine-d₆is intended for use as an internal standard for the quantification of rilpivirine by GC- or LC-MS. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC₅₀value of 0.51 nM.¹It is active against NNRTI-resistant HIV strains with EC₅₀values of less than 1 nM for L100I, K103N, V106A, G190A, and G190S mutantsin vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates (EC₅₀s =<10 nm), including strains containing up to eight resistance mutations.In vivo, rilpivirine, when used in combination with cabotegravir, lamivudine , and abcavir, reduces the plasma viral titer in HIV-1 infected humanized mice.²

1.Garvey, L., and Winston, A.Rilpivirine: A novel non-nucleoside reverse transcriptase inhibitorExpert Opin. Drug Discov.18(7)1035-1041(2009) 2.Arainga, M., Edagwa, B., Mosley, R.L., et al.A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapyRetrovirology14(1)17(2017)