An internal standard for the quantification of valdecoxib
货号:ajcx23704
CAS:1219794-90-7
分子式:C16H11D3N2O3S
分子量：317.4
溶解度:DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Valdecoxib-d₃is intended for use as an internal standard for the quantification of valdecoxib by GC- or LC-MS. Valdecoxib is a selective inhibitor of COX-2 (IC₅₀s = 0.005 and 140 µM, for human recombinant COX-2 and COX-1, respectively).¹It decreases LPS-induced production of prostaglandin E₂in isolated human whole blood (IC₅₀= 0.89 µM). Valdecoxib reduces carrageenan-induced paw edema and adjuvant-induced arthritis in rats (ED₅₀s = 10.2 and 0.032 mg/kg, respectively).

1.Talley, J.J., Brown, D.L., Carter, J.S., et al.4-[5-Methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: A potent and selective inhibitor of COX-2J. Med. Chem.43(5)775-777(2000)