A neuropeptide with diverse biological activities
货号:ajcx23710
CAS:N/A
分子式:C8H11D4O2.Na
分子量：170.2
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Valproic acid-d₄(sodium salt) is intended for use as an internal standard for the quantification of valproic acid by GC- or LC-MS. Valproic acid is an analog of the natural fatty acid valeric acid that inhibits class I histone deacetylases (HDACs) with an IC₅₀value of approximately 2 mM.¹It decreases the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia, an effect that is reversed by inositol-1,4,5-trisphosphate (1,4,5-IP₃).²In vivo, valproic acid inhibits amyloid-β deposition and neuritic plaque formation and decreases escape latency in the Morris water maze, indicating improved memory performance, in the APP23 transgenic mouse model of Alzheimer's disease.³Valproic acid has anticonvulsant activity in the pentylenetetrazol seizure threshold test in mice (ED₅₀= 0.71 mmol/kg) but induces neurotoxicity when administered at doses greater than or equal to 1.2 mmol/kg.⁴Formulations containing valproic acid have been used to treat bipolar disorder and various seizure disorders.

1.GÖttlicher, M., Minucci, S., Zhu, P., et al.Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cellsEMBO J.20(24)6969-6978(2001) 2.Williams, R.S.B., Cheng, L., Mudge, A.W., et al.A common mechanism of action for three mood-stabilizing drugsNature417(6886)292-295(2002) 3.Qing, H., He, G., Ly, P.T., et al.Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse modelsJ. Exp. Med.205(12)2781-2789(2008) 4.Elmazar, M.M., Hauck, R.S., and Nau, H.Anticonvulsant and neurotoxic activities of twelve analogues of valproic acidJ. Pharm. Sci.82(12)1255-1258(1993)