A PAD2 and PAD4 inhibitor
货号:ajcx23752
CAS:2309756-20-3
分子式:C27H32ClN5O2.HCl
分子量：530.5
溶解度:Methanol: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC₅₀s = 0.5-1 and 1-5 μM, respectively).¹It inhibits the growth of U2OS osteosarcoma cells (IC₅₀= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.²

1.Wang, Y., Li, P., Wang, S., et al.Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activityThe Journal of Biological Chemisty287(31)25941-25952(2012) 2.Wang, S., Chen, X.A., Hu, J., et al.ATF4 gene network mediates cellular response to the anticancer PAD inhibitor YW3-56 in triple-negative breast cancer cellsMol. Cancer Ther.14(4)877-888(2015)