A synthetic GNRH peptide agonist
货号:ajcx25900
CAS:2240176-35-4
分子式:C64H82N18O13 • XCF3COOH
分子量：1311.4
溶解度:DMF: 10mg/mL,DMSO: 3mg/mL,PBS (pH 7.2): 3mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; K_i= 0.3 nM in CHO cells expressing the human receptor).¹It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC₅₀s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).²Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC₅₀s = 58.29 and 31.59 μM, respectively).³It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM.²It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day.⁴Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.

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