| 规格: | 98% |
| 分子量: | 333.38 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
Background:
Lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 μM). Inhibits binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively.
Mori et al (2013) Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem.J. 455 339 PMID:23981180
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