DMH2 是一种有效的 BMP 受体拮抗剂。 DMH2 下调 Id1 和 Id3 蛋白的表达，抑制肺癌细胞系的增殖并诱导细胞死亡。
货号:ajcx27130
CAS:1206711-14-9
分子式:C27H25N5O2
分子量：451.52
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.

Tsugawa et al (2014) Specific AVNreceptor-like kinase 3 inhibitors enhance liver regeneration. J.Pharmacol.Exp.Ther. 351 549 PMID:25271257