CP 424174 是一种可逆的 IL-1β 加工抑制剂，IC50 为 210 nM。
货号:ajcx27382
CAS:210825-31-3
分子式:C22H29ClN2O4S
分子量：452.99
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Inhibitor of IL-1β post-translational processing (IC50 = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

Perregaux et al (2001) Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J.Pharmacol.Exp.Ther. 299 187 PMID:11561079 |Baldwin et al (2016) Inhibiting the inflammasome: a chemical perspective. J.Med.Chem. 59 1691 PMID:26422006