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AD 01
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AD 01图片
包装:1mg
规格:98%
市场价:3184元
分子量:2703.94

产品介绍
AD 01 是一种 24 个氨基酸的 FKBPL(FK506 结合蛋白样)肽,具有有效的抗血管生成活性。 AD 01 与 CD44 受体结合并以 CD44 依赖性方式抑制肿瘤细胞迁移。
货号:ajcx27836
CAS:959961-23-0
分子式:C115H187N33O42
分子量:2703.94
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

FKBPL (FK506-binding protein like)-based peptide. Binds to and upregulates expression of CD44. Inhibits breast cancer stem cell (BCSC) growth. Decreases pluripotency markers and promotes differentiation of BCSCs. Also inhibits endothelial cell migration as well as tubule and microvessel formation in vitro and in vivo. Blocks tumor growth in xenograft models.


Yakkundi et al (2013) The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway. PLoS One. 8 e55075 PMID:23457460 |McClements et al (2013) Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway. Clin.Cancer Res. 19 3881 PMID:23741069 |Valentine et al (2011) FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism. Clin.Cancer Res 17 1044 PMID:21364036