Guvacine是一种在槟榔中发现的生物碱，是一种有效的GABA摄取抑制剂。Guvacine抑制大鼠GAT-1，大鼠GAT-2和大鼠GAT-3的IC50值分别为39μM，58μM和378μM。
货号:ajcx30748
CAS:498-96-4
分子式:C6H9NO2
分子量：127.14
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].

[1]. L A Borden, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.