MEISi-2 是一种选择性的 MEIS 抑制剂，MEIS 是造血干细胞 (HSC) 自我更新的关键调控因子。MEISi-2 被开发用于心脏损伤、造血问题、骨髓移植和癌症的研究。
货号:ajcx33448
CAS:2250156-71-7
分子式:C18H14N2O3
分子量：306.32
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer[1].

MEISi-2 does not significantly inhibit the PBX-Luc-reporter[1].MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal[1].MEISi-2 down-regulates MEIS target gene expression[1].MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo[1].

MEISi-2 (10 µM; i.p.; at day 1, day 4 and day 7) functionally inhibits MEIS in vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48- HSC content[1].MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF[1].

[1]. Raife Dilek Turan, et al. Development of Small Molecule MEIS Inhibitors that modulate HSC activity. Sci Rep. 2020; 10: 7994.