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Tulobuterol-D9 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tulobuterol-D9 hydrochloride图片
规格:98%
分子量:273.25
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Tulobuterol-D9 hydrochloride (C-78-D9) 是 Tulobuterol 的氘代物。Tulobuterol (C-78 free base) 是一种长效的 β2 肾上腺素受体 (β2-adrenoceptor) 激动剂,可减少慢性阻塞性肺疾病和支气管哮喘的发作频率。Tulobuterol 也是一种拟交感神经药,用作透皮贴剂,可增加正常的横膈膜肌肉力量。
货号:ajcx35508
CAS:1325559-14-5
分子式:C12H10D9Cl2NO
分子量:273.25
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Tulobuterol-D9 hydrochloride (C-78-D9) is the deuterium labeled Tulobuterol. Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Yamaya M, et al. Tulobuterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Physiol Rep. 2013 Aug;1(3):e00041.;Shindoh C, et al. Tulobuterol patch maintains diaphragm muscle contractility for over twenty-four hours in a mouse model of sepsis. Tohoku J Exp Med. 2009 Aug;218(4):271-8.