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AS-0141
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AS-0141图片
规格:98%
分子量:465.43
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM),具有抗肿瘤活性,详情请参考文献 WO2019165473A1,compound I-D。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶,在细胞周期中对 DNA 复制的启动至关重要。
货号:ajcx35560
CAS:1402057-88-8
分子式:C21H22F3N5O4
分子量:465.43
溶解度:DMSO : 83.33 mg/mL (179.04 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM), extracted from patent WO2019165473A1, compound I- D, has anti-tumor activity[1][2].

AS-0141 (Cdc7-IN-6) demonstrates potent inhibitory activity (IC50<3 µμ) in a range of solid tumor cell lines, including those of bladder (5673, RT1 12/84), sarcoma (143B, CADO-ES1, RD-ES, A673), colon and cecum (Colo-205, DLD-l, LS1034, SK-CO-l, SNU-C1), renal (U0.31), head-and-neck (CNE-2Z, RPMI-2650), melanoma (A2058, A875), and gastric (HGC-27) lineages[1].

[1]. Christian Andrew HASSIG, et al. Methods of treatment of cancer comprising cdc7 inhibitors. WO2019165473A1.