Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷，用于治疗充血性心力衰竭和因折返机制引起的室上性心律失常，并在治疗慢性心房颤动时控制心室率。Deslanoside 抑制Na-K-ATPase膜泵，导致细胞内钠和钙浓度增加。
货号:ajcx15590
CAS:17598-65-1
分子式:C47H74O19
分子量：943.08
溶解度:DMSO: 100 mg/mL (106.04 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations [1][2][3].

Deslanoside (Desacetyllanatoside C) is a metabolite of Lanatoside C[4]. Deslanoside increases forearm blood flow and cardiac index and decreased heart rate concomitant with a marked decrease in skeletal muscle sympathetic nerve activity measured as an indicator of centrally mediated sympathetic nervous system activity[1].

[1]. Hauptman PJ, et al. Digitalis. Circulation. 1999 Mar 9;99(9):1265-70. [2]. Wang L, et al. Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China. Sci Rep. 2017 Oct 23;7(1):13819. [3]. Deslanoside. [4]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8. [5]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.