A Certified Reference Material
货号:ajcx21510
CAS:1435727-11-9
分子式:C20H22D3NO4
分子量：346.4
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

6β-Naltrexol-d₃is an analytical reference material intended for use as an internal standard for the quantification of 6β-naltrexol by GC- or LC-MS. 6β-Naltrexol is the major metabolite of naltrexone .¹It is a neutral µ-opioid receptor antagonist (K_i= 94 pM).^2,3This product is intended for research and forensic applications.

1.Porter, S.J., Somogyi, A.A., and White, J.M.Kinetics and inhibition of the formation of 6β-naltrexol from naltrexone in human liver cytosolBr. J. Clin. Pharmacol.50(5)465-471(2000) 2.Wang, D., Raehal, K.M., Bilsky, E.J., et al.Inverse agonists and neutral antagonists at μ opioid receptor (MOR): Possible role of basal receptor signaling in narcotic dependenceJ. Neurochem.77(6)1590-1600(2007) 3.Porter, S.J., Somogyi, A.A., and White, J.M.In vivo and in vitro potency studies of 6β-naltrexol, the major human metabolite of naltrexoneAddict. Biol.7(2)219-225(2002)