A neuropeptide with diverse biological activities
货号:ajcx22964
CAS:N/A
分子式:C25H8D15BO2P.Br
分子量：492.2
溶解度:DMF: 5 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MitoB-d₁₅is intended for use as an internal standard for the quantification of MitoB by GC- or LC-MS. MitoB is a ratiometric mass spectrometry probe that can be used for assessing changes in H₂O₂within mitochondriain vivo. MitoB contains a triphenylphosphonium cation component that drives its accumulation in mitochondria where its arylboronic moiety selectively reacts with H₂O₂to produce a phenol product, MitoP .^1,2Quantifying the MitoP/MitoB ratio by LC-MS/MS reflects the mitochondrial matrix H₂O₂concentration.

1.CochemÉ, H.M., Logan, A., Prime, T.A., et al.Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living DrosophilaNature Protocols7(5)946-958(2012) 2.CochemÉ, H.M., Quin, C., McQuaker, S.J., et al.Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrixCell Metabolism13(3)340-350(2011)