An inhibitor of EAAT1 and EAAT2
货号:ajcx23586
CAS:N/A
分子式:C19H17F3N2O6.XH2O
分子量：426.3
溶解度:DMSO: 30 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TFB-TBOA is an inhibitor of excitatory amino acid transporter 1 (EAAT1) and EAAT2 with IC₅₀values of 22 and 17 nM for EAAT1 and EAAT2, respectively, in a glutamate uptake assay using COS-1 cells.¹It is selective for EAAT1 and EAAT2 over EAAT3 (IC₅₀= 300 nM), as well as the choline, dopamine, GABA, norepinephrine, and serotonin transporters and a variety of neurotransmitter receptors at 10 µM. TFB-TBOA (10 µM) inhibits L-glutamate- and L-aspartate-induced currents inX. laevisoocytes. It induces convulsions in mice when administered at a dose of 0.2 µg/animal.

1.Shimamoto, K., Sakai, R., Takaoka, K., et al.Characterization of novel L-threo-β-benzyloxyaspartate derivatives, potent blockers of the glutamate transportersMol. Pharmacol.65(4)1008-1015(2004)