An intermediate in GSH synthesis
货号:ajcx23818
CAS:N/A
分子式:C8H14N2O5S.XNH4
分子量：250.3
溶解度:PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

γ-Glu-Cys is an intermediate in glutathione (GSH) synthesis.¹It is formed by ATP-dependent condensation of cysteine and glutamate by γ-glutamylcysteine synthetase. γ-Glu-Cys is also an essential component of phytochelatins, the heavy metal detoxifying enzymes in plants.²

1.Anderson, M.E., and Meister, A.Transport and direct utilization of γ-glutamylcyst(e)ine for glutathione synthesisProc. Natl. Acad. Sci. USA80(3)707-711(1983) 2.Grill, E., LÖffler, S., Winnacker, E.-L., et al.Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific γ-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase)Proc. Natl. Acad. Sci. USA86(18)6838-6842(1989)