A peptide NMUR agonist
货号:ajcx25492
CAS:N/A
分子式:C124H180N34O31·XCF3COOH
分子量：2643
溶解度:DMSO: 1 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Neuromedin U-23 (NMU-23) is a neuropeptide involved in diverse biological processes, including smooth muscle contraction, energy homeostasis, and nociception.¹It is an agonist of neuromedin-U receptor 1 (NMUR1; EC₅₀= 0.17 nM for the human receptor in a calcium mobilization assay using HEK293 cells) and NMUR2 (EC₅₀= ~1.4-2 nM for arachidonic acid release in CHO cells expressing the human receptor).^2,3NMU-23 (1 µM) induces contractions in isolated rat colon smooth muscle strips.⁴It decreases body weight and food intake and increases core body temperature in mice when administered at a dose of 36 µg/animal.⁵Intrathecal administration of NMU-23 decreases the mechanical pain threshold in the von Frey test in rats.⁶

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