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Safranal
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Safranal图片
包装:500mg
规格:98%
市场价:445元
分子量:150.22

产品介绍
Safranal是藏红花(Crocussativus)的主要成分,具有口服活性,是这种香料的独特香气来源。Safranal具有神经保护和抗炎作用,并有用于帕金森氏病的研究潜力。
货号:ajcx29672
CAS:116-26-7
分子式:C10H14O
分子量:150.22
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson's disease research[1].

Safranal (10-50 μM; for 1 h) dose-dependently decreases LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs[1]. Safranal (10-50 μM; for 1 h) inhibits cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells[1]. Safranal (10, 50 μM; for 1 h followed by stimulation with 1 μg/ml of LPS for 30 min) inhibits the nuclear translocation of NF-κB and AP-1 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells[1]. Western Blot Analysis[1] Cell Line: RAW264.7 cells and bone marrow-derived macrophages (BMDMs)

Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low[1]. Animal Model: Female BALB/c mice (18-20 g) (DSS-induced colitis mice)[1]

[1]. Peeraphong Lertnimitphun, et al. Safranal Alleviates Dextran Sulfate Sodium-Induced Colitis and Suppresses Macrophage-Mediated Inflammation. Front Pharmacol. 2019 Nov 1;10:1281.