AUNP-12(NP-12)TFA是PD-1信号通路的一种多肽拮抗剂，在抑制淋巴细胞增殖和效应功能方面对PD-L1和PD-L2具有等效的拮抗作用。AUNP-12TFA具有免疫激活作用、良好的抗肿瘤活性，具有更好的研究免疫相关不良事件(irAEs)的潜力。
货号:ajcx30206
CAS:N/A
分子式:C142H226N40O48.C2HF3O2
分子量：3375.57
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AUNP-12 TFA (NP-12 TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 TFA exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs)[1].

NP-12 TFA displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions [1].NP-12 TFA rescues the proliferation in the mouse splenocyte assay system with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively [1].NP-12 TFA is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively [1].

[1]. Sasikumar PG, et al. A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 2019 Jun;18(6):1081-1091.