PKAInhibitorFragment(6-22)amideTFA是cAMP依赖性蛋白激酶A(PKA)的抑制剂，Ki值为2.8nM。PKAInhibitorFragment(6-22)amideTFA可显着逆转小鼠低水平的吗啡镇痛感受性。
货号:ajcx31914
CAS:N/A
分子式:C82H131F3N28O26
分子量：1982.08
溶解度:H2O: 50 mg/mL (25.23 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse low-level morphine antinociceptive tolerance in mice[1][2].

[1]. Katz BM, et, al. Synthesis, characterization and inhibitory activities of (4-N3[3,5-3H]Phe10)PKI(6-22)amide and its precursors: photoaffinity labeling peptides for the active site of cyclic AMP-dependent protein kinase. Int J Pept Protein Res. 1989 Jun;33(6):439-45. [2]. Dalton GD, et, al. Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI). Neuropharmacology. 2005 Apr; 48(5): 648-57.