XY028-140 是一种选择性 CDK4/CDK6 降解剂。XY028-140 抑制癌细胞中的 CDK4/6 表达和 CDK4/6 活性。
货号:ajcx33130
CAS:2229974-83-6
分子式:C39H40N10O7
分子量：760.8
溶解度:DMSO : 5.56 mg/mL (7.31 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

XY028-140 is a selective CDK4/CDK6 degrader. XY028-140 inhibits both CDK4/6 expression and CDK4/6 activity in cancer cells[1].

A375 melanoma and T47D breast cancer cells are treated with 0.3 or 1 µμ XY028-140 for 24 hours. XY028-140 inhibits both CDK4/6 expression and CDK4/6 activity[1]. T47D breast cancer cells are treated with 0.03, 0.1, 0.3, 1, or 3 µμ XY028-140 for 11 days. XY028-140 inhibits cancer cell proliferation in breast cancer cells[1].

[1]. Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. WO2018106870A1.