SGC3027 是一种组蛋白甲基转移酶抑制剂。SGC3027 是第一个有效，选择性，具有细胞活性的?PRMT7?化学探针。
货号:ajcx12142
CAS:2624313-13-7
分子式:C??H??ClN?O?S
分子量：787.37
溶解度:DMSO : 250 mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SGC3027 is a?histone methyltransferase?inhibitor^[1]. SGC3027 is the first potent, selective and cell active chemical probe for?PRMT7^[2]

SGC3027 is a pro-drug of SGC8158 which releases the active component upon reduction in the cell by reductases. In cellular assays using C2C12 cells, SGC3027 inhibits the methylation of HSP70 with IC₅₀=1.3 μM^[2].