KDM5-C70 是一种 KDM5-C49 的乙酯衍生物，是一种有效的，细胞可渗透的泛 KDM5 组蛋白脱甲基酶抑制剂。KDM5-C70 在骨髓瘤细胞中具有抗增殖作用，从而导致 H3K4me3 水平在全基因组范围内升高。
货号:ajcx16548
CAS:1596348-32-1
分子式:C17H28N4O3
分子量：336.43
溶解度:DMSO: 250 mg/mL (743.10 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels[1][2].

[1]. Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45. [2]. Blair LP, et al. KDM5 lysine demethylases are involved in maintenance of 3'UTR length. Sci Adv. 2016 Nov 18;2(11):e1501662.