您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > 5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine图片
规格:98%
分子量:409.5
包装与价格：
包装价格(元)
250ug电议
500ug电议
1mg电议

产品介绍
An mPGES-1 inhibitor
货号:ajcx21458
CAS:2253745-70-7
分子式:C27H27N3O
分子量：409.5
溶解度:Chloroform: 10 mg/ml,Ethanol: 10 mg/ml,Methyl Acetate: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 117 and 60 nM for the human and mouse enzymes, respectively).1It inhibits LPS-induced prostaglandin E2production in mouse peritoneal cells (IC50= 31 nM).In vivo, 5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.


1.Kal?ic, F., Kolman, V., Ajani, H., et al.Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edemaChemMedChem15(15)1398-1407(2020)