An internal standard for the quantification of prostaglandin A2
货号:ajcx23318
CAS:201608-18-6
分子式:C20H26D4O4
分子量：338.5
溶解度:DMF: >75 mg/ml (from PGA1),DMSO: >50 mg/ml (from PGA1),Ethanol: >100 mg/ml (from PGA1),PBS pH 7.2: >2.4 mg/ml (from PGA1)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Prostaglandin A₂-d₄(PGA₂-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGA₂by GC-or LC-mass spectrometry. PGA₂is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. It has low biological potency in most bioassays, but does show some antiviral/antitumor activity.¹At a 25 µM concentration, PGA₂blocks the cell cycle progression of NIH 3T3 cells at the G₁and G₂/M phase.²It has also been shown to act as a vasodilator with natriuretic properties.³

1.Fukushima, M., Kato, T., Narumiya, S., et al.Prostaglandin A and J: Antitumor and antiviral prostaglandinsAdv. Prostaglandin Thromboxane Leukot. Res.19415-418(1989) 2.Hitomi, M., Shu, J., Strom, D., et al.Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulationJ. Biol. Chem.271(16)9376-9383(1996) 3.Frolich, J.C., Sweetman, B.J., Carr, K., et al.Assessment of the levels of PGA2 in human plasma by gas chromatography-mass spectrometryProstaglandins10(1)185-195(1975)