An acyl-CoA thioester
货号:ajcx25864
CAS:N/A
分子式:C39H68N7O17P3S • Na
分子量：1055
溶解度:Water: 10mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Oleoyl-coenzyme A (oleoyl-CoA) is a thioester of oleic acid and CoA . It is a substrate for several acyl-CoA-dependent enzymes, including acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), ACAT-2, acyl-CoA dehydrogenase-9 (ACAD-9), membrane-bound O-acyltransferase 1 (MBOAT1), and MBOAT2.^1,2,3Oleoyl-CoA binds the fatty acid metabolism regulator protein (FadR) promoter inE. coli(K_i= 0.005 µM).⁴Oleoyl-CoA (1 µM) activates sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel K_ir6.2 inXenopusoocytes.⁵

1.Seo, T., Oelkers, P.M., Giattina, M.R., et al.Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cellsBiochemistry40(15)4756-4762(2001) 2.Ensenauer, R., He, M., Willard, J.-M., et al.Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial β-oxidation of unsaturated fatty acidsJ. Biol. Chem.280(37)32309-32316(2005) 3.GijÓn, M.A., Riekhof, W.R., Zarini, S., et al.Lysophospholipid acyltransferases and arachidonate recycling in human neutrophilsJ. Biol. Chem.283(44)30235-30245(2008) 4.DiRusso, C.C., Heimert, T.L., and Metzger, A.K.Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme AJ. Biol. Chem.267(12)8685-8691(1992) 5.Gribble, F.M., Proks, P., Corkey, B.E., et al.Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoAJ. Biol. Chem.273(41)26383-26387(1998)