| 规格: | 98% |
| 分子量: | 452.5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
Background:
Olmesartan-d6is intended for use as an internal standard for the quantification of olmesartan by GC- or LC-MS. Olmesartan is a non-peptide angiotensin II receptor 1 (AT1) antagonist (IC50= 0.0077 µM for the bovine adrenal cortex receptor) and an active metabolite of olmesartan medoxomil .1It is formed from olmesartan medoxomil by paraoxonase 1 (PON1) in human plasma.2Olmesartan is selective for AT1over AT2(IC50= >100 µM for the bovine cerebellar receptor). It reduces contraction of isolated guinea pig aorta induced by angiotensin II but not phenylephrine or potassium chloride. Olmesartan (0.01 and 0.03 mg/kg, i.v.) reduces the angiotensin II-induced pressor response in conscious normotensive rats.
1.Mizuno, M., Sada, T., Ikeda, M., et al.Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonistEur. J. Pharmacol.285(2)181-188(1995) 2.Ishizuka, T., Fujimori, I., Nishida, A., et al.Paraoxonase 1 as a major bioactivating hydrolase for olmesartan medoxomil in human blood circulation: Molecular identification and contribution to plasma metabolismDrug Metab. Dispos.40(2)374-380(2012)
m.cnreagent.com