| 包装: | 10mg |
| 规格: | 98% |
| 市场价: | 3083元 |
| 分子量: | 551.47 |
Background:
Cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.
Rillahan et al (2012) Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat.Chem.Biol. 8 661 PMID:22683610 |Büll et al (2015) Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread. ACS Nano. 9 733 PMID:25575241
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