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JWH 203 N-(4-hydroxypentyl)metabolite-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JWH 203 N-(4-hydroxypentyl)metabolite-d5图片
规格:98%
分子量:360.9
包装与价格:
包装价格(元)
100ug电议
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22742
CAS:N/A
分子式:C21H17D5ClNO2
分子量:360.9
溶解度:DMF: 10 mg/ml,DMSO: 5 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

JWH 203 N-(4-hydroxypentyl) metabolite-d5contains five deuterium atoms at the 2, 4 ,5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of JWH 203 N-(4-hydroxypentyl) metabolite by GC-or LC-mass spectrometry. JWH 203 is an analgesic chemical from the phenylacetylindole family that acts as an agonist with Kivalues of 8.0 and 7.0 nM at the central cannabinoid (CB1) and peripheral (CB2) receptors, respectively.1Similar to the related 2'-methoxy compound JWH 250 , JWH 203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds. Compared to JWH 250, JWH 203 displays slightly more potent binding affinities for the CB1and CB2receptors (JWH 250 Kis = 11 and 33 nM, respectively).1JWH 203 N-(4-hydroxypentyl) metabolite is expected to be a metabolite of JWH 203 that would be detectable both in serum and in urine. While similar hydroxylated phase I metabolites of synthetic CBs retain activity, the physiological properties of this compound have yet to be determined.2,3This product is intended for research and forensic applications.


1.Huffman, J.W., Szklennik, P.V., Almond, A., et al.1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indolesBioorg. Med. Chem. Lett.15(18)4110-4113(2005) 2.Brents, L.K., Reichard, E.E., Zimmerman, M., et al.Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activityPLoS One6(7)1-9(2011) 3.Brents, L.K., Gallus-Zawala, A., Radominska-Pandya, A., et al.Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retainintermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutralantagonist to partial agonist activityBiochemical Pharmacology83952-961(2012)