CIL62是一种不依赖caspase-3/7的细胞死亡诱导剂。其作用机制是Necrostatin-1依赖性细胞死亡。
货号:ajcx30400
CAS:117593-36-9
分子式:C23H26O5
分子量：382.45
溶解度:DMSO: 125 mg/mL (326.84 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CIL62 is a caspase-3/7-independent cell death inducer. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death[1].

19 µM (5 µg/mL) Necrostatin-1 suppresses CIL62, but CIL62 is not suppressed by the ferroptosis inducers (antioxidants or iron-chelators)[1].

[1]. Kenichi Shimada, et al. Global Survey of Cell Death Mechanisms Reveals Metabolic Regulation of Ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503.